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                                                  島雄大介氏提供

 The first advantage of X-ray is its ability of penetration. Therefore, it is used in internal observation of human body. X-ray uses the principle of the shadowgraph using the different absorption of each tissue. However, absorption difference between the cancer tissue and the normal tissue is very small. When the cancer tissue is not big enough, the absorption contrast does not rise. Thus, cancer in early stage is hard to be detected. To develop a method to detect the cancer tissue in early stage, using the other properties of x-ray like phase, refraction, scattering, fluorescence and so on should be good. In this 5, 6 years of research, the principle used in this research is the refraction. The amount of はずれin x-ray refraction rate is very small(10e-6~10e-7). As a result, confirmation of refraction is not easy compare to visible light. However, by using x-ray optical system (double-crystal arrangement which uses silicon monocrystal) the refraction is distinguishable.。
  1 or 2 pieces of roentgenograms or CT 3-D images are taken when we have a medical checkup. Therefore the development of CT algorithm corresponding to refraction principle which replaces the old CT base on the absorption principle is required because CT image is also desired in the medical site. Furthermore, we are challenging to develop an algorithm on reducing radiation exposure dose which is requested in clinical site.


<Thesis List>

Computed Tomographic Reconstruction Based on X-Ray Refraction Contrast
Anton Maksimenko, Masami Ando, Hiroshi Sugiyama, Tetsuya Yuasa
Appl. Phys. Lett. 86 (2005) 124105-1~124105-3.

Possibility of Computed Tomographic Reconstruction of Cracks from the X-ray Refraction Contrast
Anton Maksimenko, Masami Ando, Hiroshi Sugiyama, Eiko Hashimoto
Jpn. J. Appl. Phys. 44, Part 2, No.3A, L633-L635, 2005.

 First application of x-ray refraction based computed tomography to a biomedical object
Eiko Hashimoto, Anton Maksimenko, Hiroshi Sugiyama, Kazuyuki Hyodo, Daisuke Shimao, Yoshinori Nishino, Tetsuya Ishikawa, Tetsuya Yuasa, Koichi Mori and Masami Ando
Zoological Science 23 (2006) 1-5.

High-Pass Filtered Diffraction Micro-Tomography by Coherent Hard X-rays for Cell Imaging: Theoretical and Numerical Studies of the Imaging and Reconstruction Principles
Tetsuya Yuasa, Hiroshi Sugiyama, Zhong Zhong, Anton Maksimenko, F. Avraham Dilmanian, Takao Akatsuka, Masami Ando
JOSA 22 (2005) 2622-2634.

2D and 3D Visualization of Ductal Carcinoma in situ (DCIS) due to X-Ray Refraction Contrast
Masami Ando, Anton Maksimenko, Tetsuya Yuasa, Eiko Hashimoto, Katsuhito Yamasaki, Chiho Ohbayashi, Hiroshi Sugiyama, Kazuyuki Hyodo, Tatsuro Kimura, Hiroyasu Esumi, Takao Akatsuka, Gang Li, Dingchang Xian, Ei Ueno, Hiroko Bando, Shu Ichihara, Tokiko Endo, Noriyuki Moriyama and Hisahide NishinoBioimages 14 (2006) 1-8.

 Hard-X-Ray Region Tomographic Reconstruction of the Refractive-index Gradient Vector Field: Imaging Principles and Comparisons with Diffraction-Enhanced-Imaging-Based Computed Tomography
Tetsuya Yuasa, Anton Maksimenko, Eiko Hashimoto, Hiroshi Sugiyama, Kazuyuki Hyodo, Takao Akatsuka, Masami Ando
Optics Letters 31 No.12 (2006) 1818-1820.













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