>>For Students
 >>
 >>Development for Early Detection of Breast Cancer
 >>Development for Early Detection of Articular Problem
 >>Joint Lessons
 >>Research Conferences
 >>Joint Research
 >>Research Facilities
 >>Introduction of Researchers
 Development for early detection of breast cancer
We have challenged to detect the Invasive Micropapillary Carcinoma as an application example of x-ray dark-field imaging in development for early detection of breast cancer. We could identify the cancer cell nest, cancer cell, interstice, normal tissue, breast cancer cell group, fatty layer, muscle, fiber and so on as shown in Figure 1. Moreover, the correspondence with figure which is pathology stained is very good.

 Therefore, if the mammography using x-ray dark-field method is established, due to the higher contrast and spatial resolution, it is possible to be applied on early detection of breast cancer. Furthermore, it is possible to get the refraction contrast image by mathematics processing数学処理 the data which is collected by CCD camera while spinning the sample and the refraction element extracted. When it is applied on non-invasive micropapillary carcinoma with a diameter of 3.5mm, length of 4.5mm, the 3-D slice image could be obtained. Breast duct, the calcification in breast duct, fibrous connective tissue around breast duct and fats can be seen clearly. From the figure, it is able to see the 3 ducts at the bottom joining into 1 duct on the top 3-dimensionally.
Fig. 1 An x-ray dark-field image of an Invasive micro-ductal carcinoma sample of 2.8mm in thickness with taken 35keV. The black section is image formed by x-ray refraction. The grey section is section where the x-ray does not reach. Because the contrast of a roentgenogram is based on the absorption, the smaller the breast cancer cell nest is or the smaller the calcification is, the lesser the contrast is when the x-ray energy is raised. At this point, the contrast based on x-ray dark-field method hardly has restrictions. a ~ g is the breast cancer cell nest.

Fig. 2 3-D image of non-invasive micro-ductal carcinoma is composed with newly developed mathematics format. The silk-liked section is duct and the white section in the duct is the part where calcification occurs. The duct and the calcified duct join and become 1 duct. It is possible that there is necrotic cancer cell in the confluence.

 >>Video


2005.04.12  Attempt at Visualizing Breast Cancer with X-ray Dark Field Imaging

20050722 Attempt at Two-Dimensional Mapping of X-ray Fluorescence from Breast Cancer Tissue

20050902 Science News

20051017 Development of technology for visualization with 2-D, 3-D X-ray refraction aiming at early detection of breast cancer

20051017  KEK Press release (Japanese) Development of technology for visualization with 2-D, 3-D X-ray refraction aiming at early detection of breast cancer

20060814 Development of X-ray imaging base on principle of refraction aiming at early detection of breast cancer

20061116 2D and 3D Visualization of Ductal Carcinoma in situ (DCIS) using X-Ray Refraction Contrast

Isotope News jun. 2006 展望

Development of technology for visualization with 2-D, 3-D X-ray refraction aiming at early detection of breast canc

Sokendai Journal 2006 p32-37

ルポ先端人

Japanese Chinese KEK explanation on Breast Cancer
Copyright  2006  Tokyo University of Science All Rights Reserved.