Compliments from the head of the Center

Professor of the Department of Pharmacy, Drug Potency Physicochemistry Class; Chief of the Center for Drug Delivery Research Doctor of pharmacology Hiroshi Terada
[Major field]
Drug potency physicochemistry
[Research field]
Molecular mechanism of drug potency development
[Research content]
The molecular mechanism of drug potency development is generalized using the confirmation change of protein and drug as an indicator that occurs upon their mutual actions. Further, a "drug delivery system utilizing the host defense system” is created.
This research proactively utilizes the phagocytic ability of macrophage and is useful for treating intractable diseases such as tuberculosis.

The molecular mechanism of drug potency development is generalized using the confirmation change of protein and drug as an indicator that occurs upon their mutual actions. Further, a "drug delivery system utilizing the host defense system” is created.
This research proactively utilizes the phagocytic ability of macrophage and is useful for treating intractable diseases such as tuberculosis.

The Center for Drug Delivery Research of the multidiscipline laboratory of the Tokyo University of Science was established as the 8th department of the multidiscipline laboratory on April 1, 2003. This research center invited researchers and clinicians as guest researchers from universities, pharmaceutical companies, and medical organizations in addition to teachers of this university mainly consisting of teachers of the Department of Pharmacy of the Tokyo University of Science and started activities.

To enhance these research activities, we applied for the “Hi-tech Research Center Development Project” for the private university academic research upgrading project conducted by the Ministry of Education, Culture, Sports, Science and Technology ? Japan. As a result, our application was adopted as a 5-five year project from fiscal year 2004 to 2009 on April 1, 2004.

The issue of this project is “development of a new drug delivery system targeting the macrophage, particularly development of a drug product absorbed via the lung intended for treating the chronic intractable infectious diseases such as tuberculosis and for treating lung cancer, and development of a low-invasion breast cancer treating method allowing for treatment without surgery” and the total project cost is 1.3 billion yen.

As a result of adoption for the Hi-tech Research Center Development Project (Hi-tech Research Project), the Center for Drug Delivery Research was established as a research center of the DDS research department belonging to the multidiscipline laboratory of the Tokyo University of Science. Research activities of the DDS research department was to be consolidated into the activities of the Center for Drug Delivery Research based on the above issue in the foreseeable future.

Then, along with the organizational reform of the multidiscipline laboratory of the Tokyo University of Science in 2005, the multidiscipline laboratory was abolished. Instead, a new total research organization consisting of the research department and research center was established. In the past, the research center was a research organization belonging to the research department. In the total research organization, however, they co-exist.

Along with this organization reform, the DDS research department was abolished. The Center for Drug Delivery Research was integrated as an organization for research on DDS to implement the research on the hi-tech research project.

The hi-tech research project is briefly described below. In fiscal year 2004, construction of the research center facility as the research base for the Center for Drug Delivery Research was started. This facility was planned as a 4-story building (total area: 2,400 m2). Its construction was started from the ceremony for sanctifying ground on July 28 (Wed.), 2004. As scheduled, the completion ceremony was conducted on March 9, 2005. Since the base for DDS research was constructed, we expect that the research will further evolve. (Details on the research facility will be reported later. For research organizations and research summaries in the research center, please refer to the respective items.)

The basic concept of research in this research center is “DDS learning from the system of the living body”. The DDS research based on this basic concept is extremely unique and the research is currently very smoothly in progress. For further evolution, your further support will be appreciated.